Efficacy of Japanese cedar pollen sublingual immunotherapy tablets for Japanese cypress pollinosis

BackgroundWe previously demonstrated the efficacy of Japanese cedar (JC) pollen sublingual immunotherapy (SLIT) tablets for treating seasonal allergic rhinitis in a clinical trial (trial no. 206-2-1) that covered 5 dispersal seasons from 2015 to 2019.ObjectiveOur aim was perform post hoc analysis 206-2-1 data evaluate JC SLIT patients with induced by cypress (JCY), related Cupressaceae species has season overlapping JC.MethodsData were analyzed 240 who received placebo during first 2015, then rerandomized receive (the PA group) or PP 18 months 2016 and 2017 seasons), observed untreated 2 years 2018 2019 seasons). The groups assigned “high” “low” subgroups if their symptoms exacerbated/did not change decreased, respectively, peak JCY period 2015. mean total nasal symptom medication scores other outcomes compared high-PP, high-PA, low-PP, low-PA periods.ResultsThe significantly lower high-PA than corresponding over 4 treatment observation. pollen–specific IgE levels increased both groups.ConclusionJC effectively suppressed pollinosis symptoms, supporting relevance immunologic cross-reactivity between allergens. We 2019. Our JC. Data periods. groups.